Advantages
- Increased production efficiency
- Increased production efficiency
- Incompatible ingredients can be formulated
- Targeted release of actives in the body, bypassing stomach acid
- Higher loading of active than traditional encapsulation methods
What do we do?
Microencapsulation is the process of encapsulating the internal core material with an outer phase material through a number of advanced techniques. This technology is implemented by the manufacturers for the encapsulation of high value bioactive, minerals, vitamins, flavours, antimicrobials, antioxidants, enzymes, probiotics and essential oils. Microencapsulation offers a number of benefits such as extending the shelf-life of products preventing their evaporation, masking the odour and taste, effective protection of the active ingredient against enzymatic degradation, targeted delivery and finally preventing oxidation of flavours and essential oils.
Consultancy
Our highly skilled multi-disciplinary team can meet the requirements of the customers providing practical solutions and rapid results. We consult with the customer to understand the challenges and get to the root cause of the problem. We then assess the most suitable microencapsulation technology and the subsequent analysis required. We also provide on-site troubleshooting and provide corrective and preventative support.
Instruments
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Droplet Generator: Our micro droplet generators are the only GMP grade droplet generator that can be used for encapsulating drugs, live cells and magnetic nanoparticles etc. These hydrogels can then be used for a number of applications in tissue engineering and regenerative medicine. The technology has been successfully used in encapsulating cells for cell therapy applications by companies such as Austrianova. |
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High pressure homogeniser: Our high pressure homogenisers, temperature and pressure parameters are extremely customisable, allowing for a high degree of operator flexibility, in order to satisfy sample-specific processing needs. |
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Spray-dryer: All our spray dryers are designed to meet the strictest requirements for health and safety and environmental protection. The spray-drier hasa moisture evaporation capacity: 1-7kg/h, Electrical heating, inlet: 300℃; outlet: 120℃, Air velocity：8-15kg/h, compressed air of nozzle: 0.5-2.0 bar. |
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Laser diffraction particle sie analyzer: The LS 13 320 offers the highest resolution, reproducibility and unsurpassed accuracy. It is a state-of-the-art, laser-based technology that permits analysis of particles without the risk of missing either the largest or the smallest particles in a sample. |
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Encapsulation methods
| Methods |
Spray Drying |
Freeze-dried |
Matrix encapsulation |
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| Particle type |
Produces dry and homogenous particles |
Uniform particles with higher quality in terms of activity, water content and stability |
Uniform liquid core beads |
| Excipients |
- Sugars
- Carbohydrates
- Polymers
- Scalable
- Starches and gum
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- Proteins
- Probiotics/prebiotics
- Functional foods and bioactives
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- Polymers
- Alginate
- Gelatin
- Wax
- Proteins
- Cellulose
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| Particle size |
Controllable particle size and morphology |
Higher product uniformity |
Highly uniform particle sizes |
| Advantages |
- Short run time
- Rapid evaporation of water and maintains low temperature in the particles
- High throughput process
- Scalable
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- Preserves a wide range of pharmaceutical formulations and highly sensitive bioactives
- Low processing temperatures
- Higher yield
- Greater product uniformity
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- Short process time
- Extremely gentle conditions
- Particle hardening in polymerization bath
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Analytical support
Structural investigations
1. Particle size analysis and morphology.
2. SEM
Method development and testing
1. Shelf-life studies
2. Delayed release studies
3. Bioactivity tests
4. Encapsulation efficiency tests
